Dungeon Degenerates: Hand of Doom takes place in the Dark Fantasy Realm of the decaying Eastern Provinces of the Würstreich. Players take escaped criminal adventurers on unsavory missions through four distinct regions, each with their own monsters & encounters. As the players explore the Würstreich, danger levels rise continuously across the map. Players must complete their mission before the Hand of Doom descends on the board, unleashing evil magic on the land.